Syphilis test: prices compared
Current prices from 9 providers, including panels that contain this test. Every price shows when we last checked it.
Medical review pendingWritten by the STD Test Prices editorial team using CDC sources
Prices
| Provider | What's included | Price | Route | Results time | Same-day? | HSA/FSA | Order |
|---|---|---|---|---|---|---|---|
| Best valueLabcorp OnDemand | Single test First To Know rapid antibody self-test (finger prick), read at home in about 15 minutes; no lab or physician service. Shipping cost is shown at checkout. All sales final. | $39 | Home kit | 1 to 4 days | No | Yes | Order (opens in a new tab) |
| STDcheck.com | Single test RPR blood test. A $6 physician fee is added per order at checkout; orders at New York labs add a 35% New York compliance fee. | $49 | Lab visit | 1 to 2 days | Yes | Yes | Order (opens in a new tab) |
| Quest DiagnosticsNot available in AZ, HI, PR | Single test Antibody test; positives confirmed at no extra cost. A $6 physician service fee is added per order. | $52 | Lab visit | 1 to 3 days | Yes | Yes | Order (opens in a new tab) |
| Labcorp OnDemand | Single test RPR blood test. Price includes the ordering provider's fee and sample collection. | $59 | Lab visit | 1 to 4 days | No | Yes | Order (opens in a new tab) |
| Everlywell | Single test Antibody test (finger prick). Free shipping. | $69 | Home kit | 5 to 7 days | No | Yes | Order (opens in a new tab) |
| Priority STD Testing | Single test RPR blood test with reflex testing. | $79 | Lab visit | 1 to 3 days | Yes | Yes | Order (opens in a new tab) |
| Wisp | Single test Finger-prick blood card. Care-team messaging only; Wisp does not treat syphilis. Free shipping both ways. | $79 | Home kit | 3 to 5 days | No | Yes | Order (opens in a new tab) |
| myLAB Box | Single test Finger prick. Free shipping only on orders of $150 or more; smaller orders pay a shipping fee shown at checkout. | $89 | Home kit | 2 to 8 days | No | Yes | Order (opens in a new tab) |
| Everlywell | Included in STD Screening Panel - Basic
Sample collected at a Quest location; all fees included; results in about 1–2 days. | $119 | Lab visit | 1 to 2 days | Yes | Yes | Order (opens in a new tab) |
| Rapid STD Testing | Single test Blood test. | $139 | Lab visit | 1 to 2 days | Yes | Yes | Order (opens in a new tab) |
| LetsGetCheckedNot available in NY | Included in Standard 5
One-time price (subscription every 3 months: $104.30). Not available in New York. No HIV test. Free shipping. Treatment, where offered, needs a $39 consultation plus medication. | $149 | Home kit | 2 to 5 days | No | Yes | Order (opens in a new tab) |
- $39
- Route
- Home kit
- Results time
- 1 to 4 days
- Same-day?
- No
- HSA/FSA
- Yes
First To Know rapid antibody self-test (finger prick), read at home in about 15 minutes; no lab or physician service. Shipping cost is shown at checkout. All sales final.
Order at Labcorp OnDemand (opens in a new tab) Single test
$49- Route
- Lab visit
- Results time
- 1 to 2 days
- Same-day?
- Yes
- HSA/FSA
- Yes
RPR blood test. A $6 physician fee is added per order at checkout; orders at New York labs add a 35% New York compliance fee.
Order at STDcheck.com (opens in a new tab)Single test
$52- Route
- Lab visit
- Results time
- 1 to 3 days
- Same-day?
- Yes
- HSA/FSA
- Yes
Not available in AZ, HI, PR
Antibody test; positives confirmed at no extra cost. A $6 physician service fee is added per order.
Order at Quest Diagnostics (opens in a new tab)Single test
$59- Route
- Lab visit
- Results time
- 1 to 4 days
- Same-day?
- No
- HSA/FSA
- Yes
RPR blood test. Price includes the ordering provider's fee and sample collection.
Order at Labcorp OnDemand (opens in a new tab)Single test
$69- Route
- Home kit
- Results time
- 5 to 7 days
- Same-day?
- No
- HSA/FSA
- Yes
Antibody test (finger prick). Free shipping.
Order at Everlywell (opens in a new tab)Single test
$79- Route
- Lab visit
- Results time
- 1 to 3 days
- Same-day?
- Yes
- HSA/FSA
- Yes
RPR blood test with reflex testing.
Order at Priority STD Testing (opens in a new tab)Single test
$79- Route
- Home kit
- Results time
- 3 to 5 days
- Same-day?
- No
- HSA/FSA
- Yes
Finger-prick blood card. Care-team messaging only; Wisp does not treat syphilis. Free shipping both ways.
Order at Wisp (opens in a new tab)Single test
$89- Route
- Home kit
- Results time
- 2 to 8 days
- Same-day?
- No
- HSA/FSA
- Yes
Finger prick. Free shipping only on orders of $150 or more; smaller orders pay a shipping fee shown at checkout.
Order at myLAB Box (opens in a new tab)Included in STD Screening Panel - Basic
$119- Chlamydia
- Gonorrhea
- Syphilis
- HIV
- Route
- Lab visit
- Results time
- 1 to 2 days
- Same-day?
- Yes
- HSA/FSA
- Yes
Sample collected at a Quest location; all fees included; results in about 1–2 days.
Order at Everlywell (opens in a new tab)Single test
$139- Route
- Lab visit
- Results time
- 1 to 2 days
- Same-day?
- Yes
- HSA/FSA
- Yes
Blood test.
Order at Rapid STD Testing (opens in a new tab)Included in Standard 5
$149- Chlamydia
- Gonorrhea
- Syphilis
+2 more
- Hepatitis B
- Trichomoniasis
- Route
- Home kit
- Results time
- 2 to 5 days
- Same-day?
- No
- HSA/FSA
- Yes
Not available in NY
One-time price (subscription every 3 months: $104.30). Not available in New York. No HIV test. Free shipping. Treatment, where offered, needs a $39 consultation plus medication.
Order at LetsGetChecked (opens in a new tab)
About this test
Syphilis is a bacterial infection that develops in stages. In the first stage it causes a sore, which CDC says often appears about 3 weeks after exposure. CDC says most sexually active adults should test for syphilis based on where they live, and recommends at least yearly tests for gay, bisexual and other men who have sex with men and for people with HIV. All pregnant people should test at the first prenatal visit.
Syphilis testing uses blood. CDC says a diagnosis needs two kinds of blood test: a nontreponemal test, such as the RPR, and a treponemal test. A positive first test leads to the second. If you've had syphilis before, the treponemal test usually stays positive for life, even after treatment, so the RPR result is used to look for a new infection.
Syphilis is treated with penicillin, usually as an injection. It is reportable in every state, and the health department keeps reports confidential.
When to test
Blood tests can be negative early in infection. CDC's 2024 lab guidance says the first sore often appears about 3 weeks after exposure, with a range of 10 to 90 days. After a possible exposure, CDC's sexual assault guidance repeats syphilis blood tests at 4 to 6 weeks and again at 3 months. If you have a sore now, see a clinician, who can test the sore directly.
Retesting
After treatment for primary or secondary syphilis, CDC recommends follow-up blood tests at 6 and 12 months to check that the RPR level is falling. The treponemal test usually stays positive for life, so a clinician uses the RPR result to judge treatment and any new infection.
Reported to public health
Positive results for this infection are reported to the state or local health department, which keeps them confidential. That includes tests you order online. What that means for your privacy
Common questions
Can I test for syphilis at home?
Some home kits include a syphilis test on finger-prick blood. A lab visit uses blood from a vein. Either way, a positive screening result is followed by a second, different test, because CDC says a diagnosis needs both types.
How soon after sex can I test for syphilis?
CDC's sexual assault guidance repeats syphilis tests at 4 to 6 weeks and at 3 months after exposure. Earlier tests can be negative even when an infection is there. If you have a sore, see a clinician now.
I had syphilis before. Will I always test positive?
Probably on one of the tests. CDC says most people with a positive treponemal test stay positive for life, even after treatment. The RPR test, which tracks the infection's activity, is used to look for a new infection, so tell the clinician about your history.
Do I need to fast before a syphilis blood test?
STD blood tests don't usually require fasting. STDcheck's FAQ, for example, mentions fasting only for its separate wellness panel. Check the prep notes on your order to be sure.
Is syphilis reported to the health department?
Yes. Syphilis is reportable in every state, including for tests ordered online. CDC says these reports are kept confidential.
Sources
- Syphilis (STI Treatment Guidelines) (opens in a new tab), CDC
- Primary and Secondary Syphilis (STI Treatment Guidelines) (opens in a new tab), CDC
- CDC Laboratory Recommendations for Syphilis Testing, United States, 2024 (MMWR) (opens in a new tab), CDC
- STI Screening Recommendations (opens in a new tab), CDC
- Getting Tested for STIs (opens in a new tab), CDC
- Syphilis Infection in Nonpregnant Adolescents and Adults: Screening (2022) (opens in a new tab), U.S. Preventive Services Task Force
- Sexual Assault and Abuse and STIs: Adolescents and Adults (STI Treatment Guidelines) (opens in a new tab), CDC
- Reporting and Confidentiality (STI Treatment Guidelines) (opens in a new tab), CDC
- STD Testing FAQ (opens in a new tab), STDcheck
- Syphilis (CDC) (opens in a new tab), CDC